Fig. 3. Effect of DSP-H1684R genetic variant on the amplitude I_CaL and I_Kto. A. Representative traces of I_CaL in donor iPSC cardiomyocytes (D1, black; D2, grey) and in PCCD cardiomyocytes (red). B. Current-voltage curves depicting the peak amplitude of I_CaL at the indicated voltages. C. Bar plot of maximal I_CaL amplitude obtained during measurements of current-voltage relationship. D. Representative traces of I_Kto in donor iPSC cardiomyocytes and in PCCD iPSC cardiomyocytes. E. Inactivation curves depicting the dependence of the peak amplitude of I_Kto measured at +60 mV on the duration of depolarizing prepulse to -20 mV. F. Maximal I_Kto amplitude reflecting amplitude of outward current at +60 mV without depolarization minus amplitude of outward current at +60 mV with 320 ms depolarization prepulse to -20 mV. G. Time of exponential inactivation of I_Kto amplitude as dependence from the duration of depolarizing prepulse to -20 mV. Asterisk reflects significance (p<0.05), for details see Materials and Methods.